規格
| 屬性 | 價值 |
| Supplier | Nexperia USA Inc. |
| Package / Case | Tape & Reel (TR),Cut Tape (CT) |
| Part Status | Active |
| Voltage - Zener(Nom)(Vz) | 15 V |
| Tolerance | ±2% |
| Power - Max | 400 mW |
| Impedance(Max)(Zzt) | 15 Ohms |
| Current - Reverse Leakage @ Vr | 50 nA @ 11 V |
| Voltage - Forward (Vf) (Max) @ If | 1.1 V @ 100 mA |
| Operating Temperature | 150°C (TJ) |
| Mounting Type | Surface Mount |
概述
Description
PDZ15B,115 likely refers to a PDZ domain labeled as 15B (in a given protein or dataset) and may include a residue range or entry tag (115). Here is a concise introduction to PDZ domains in general, which covers the likely context.
- What is a PDZ domain? A modular protein interaction domain (~80–90 aa) found in scaffolding proteins such as PSD-95, SAP, Dlg, and ZO-1. It folds as a beta-sandwich with an N-terminal and a C-terminal binding groove that recognizes short C-terminal peptide motifs of partner proteins.
- Binding motifs (classical): Class I (S/T-X-Φ-COOH), Class II (Φ-X-Φ-COOH), Class III (D/E-X-Φ-COOH), where Φ is a hydrophobic residue. The GLGF loop is a hallmark that helps form the peptide-binding pocket.
- Roles: Assemble signaling complexes at membranes (e.g., synapses, tight junctions); can function as scaffolds, determine subcellular localization, and regulate signaling through post-translational modifications or alternative splicing.
- If you can share the specific protein name, UniProt ID, or organism for PDZ15B,115, I can tailor a focused intro with structure, partners, and relevance.
- What is a PDZ domain? A modular protein interaction domain (~80–90 aa) found in scaffolding proteins such as PSD-95, SAP, Dlg, and ZO-1. It folds as a beta-sandwich with an N-terminal and a C-terminal binding groove that recognizes short C-terminal peptide motifs of partner proteins.
- Binding motifs (classical): Class I (S/T-X-Φ-COOH), Class II (Φ-X-Φ-COOH), Class III (D/E-X-Φ-COOH), where Φ is a hydrophobic residue. The GLGF loop is a hallmark that helps form the peptide-binding pocket.
- Roles: Assemble signaling complexes at membranes (e.g., synapses, tight junctions); can function as scaffolds, determine subcellular localization, and regulate signaling through post-translational modifications or alternative splicing.
- If you can share the specific protein name, UniProt ID, or organism for PDZ15B,115, I can tailor a focused intro with structure, partners, and relevance.
Equivalent
I don’t recognize PDZ15B,115 unambiguously—can you give the manufacturer or a photo? If it’s a 15 V Zener, common equivalents by power/package are: BZX84C15 (SMD, ~0.5 W), BZT52H‑B15 (SOD‑123, ~0.5–1 W), or 1N4744A (through‑hole, 1 W). Choose by power dissipation, package and tolerance—send more details for an exact match.
Application
Assuming PDZ15B and PDZ115 refer to PDZ-domain containing proteins/domains, common application areas include:
- Research tools for mapping protein–protein interactions and signaling networks (PPI assays, pull-downs, colocalization)
- Drug discovery: designing inhibitors/peptidomimetics to block PDZ-mediated interactions
- Neuroscience: studying synaptic receptor clustering, trafficking, plasticity, learning and memory
- Disease research: cancer and cardiovascular signaling where PDZ interactions regulate receptor trafficking and pathways
- Diagnostics/biomarkers: PDZ-interaction signatures as disease indicators
- Synthetic biology: engineered PDZ scaffolds for modular signaling and biosensors
- Research tools for mapping protein–protein interactions and signaling networks (PPI assays, pull-downs, colocalization)
- Drug discovery: designing inhibitors/peptidomimetics to block PDZ-mediated interactions
- Neuroscience: studying synaptic receptor clustering, trafficking, plasticity, learning and memory
- Disease research: cancer and cardiovascular signaling where PDZ interactions regulate receptor trafficking and pathways
- Diagnostics/biomarkers: PDZ-interaction signatures as disease indicators
- Synthetic biology: engineered PDZ scaffolds for modular signaling and biosensors
Package
I don’t have enough info to be certain — PDZ15B,115 can refer to different manufacturers’ 15 V Zener parts. Please provide the manufacturer or a datasheet/link (or the full ordering code) and I’ll tell you the exact package type.
