NUP1301

You may mean NUP130 (nucleoporin 130 kDa). If you meant NUP1301 specifically, please specify the organism or context. Here’s a concise intro to NUP130:
- Identity: NUP130 is a core nucleoporin of the nuclear pore complex (NPC), with a ~130 kDa protein size.
- Localization: Localizes to the nuclear envelope as part of the NPC.
- Function: Contributes to NPC architecture and regulates nucleocytoplasmic transport; part of the scaffold that supports cargo docking and translocation.
- Interactions: Interacts with other NPC components (e.g., members of the Nup107-160-like scaffolding and FG-nucleoporins).
- Expression/essentiality: Ubiquitously expressed and generally essential for normal NPC function and viability; loss or disruption impairs transport.
- Clinical/research context: Altered NUP130 expression or function has been studied in cancer and other diseases related to nucleocytoplasmic transport.
If you provide the organism or a specific aspect (structure, function, disease), I can tailor the intro further.

NUP130 (nucleoporin 130 kDa) features summary:
- Location: component of the nuclear pore complex (NPC) at the nuclear envelope.
- Size: ~130 kDa; a large nucleoporin.
- Complex association: part of the NPC scaffold, associated with the Nup107–160 subcomplex and related NPC subunits.
- Function: contributes to NPC architecture and stability; supports nucleocytoplasmic transport and, indirectly, mRNA export.
- Structure: predominantly coiled-coil, structural (not primarily FG-repeat–rich like transporters).
- Interactions: engages with other nucleoporins (e.g., Nup107, Nup160, Nup133, Nup93, Nup96, etc.) and transport receptors.
- Regulation: present as a stable NPC component; can be modulated by cell-cycle–dependent phosphorylation.
- Essentiality: generally essential for viability; depletion disrupts NPC integrity and cargo transport.
- Conservation: highly conserved across eukaryotes.

There isn’t a single manufacturer of the NUP1301. It’s a standard cylindrical roller bearing designation used by several brands, including NSK, NTN, SKF, and FAG (Schaeffler). These are multinational industrial companies that specialize in bearings and precision mechanical components for automotive, aerospace, and general machinery.

Assuming you mean NUP130 (a nucleoporin of the nuclear pore complex).
- Basic research: NPC architecture, cargo docking, and nucleocytoplasmic transport mechanisms.
- Cell biology: regulation of mRNA export, protein import, and NPC assembly during the cell cycle.
- Disease research: dysregulation linked to cancer, neurodegenerative diseases, and viral infections; potential biomarker.
- Therapeutics: targeting nuclear transport to develop antiviral or anticancer strategies.
- Biotechnology: engineering NPC components for controlled transport; assays to screen transport defects and inform synthetic biology.